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Since methocarbamol may cause dizziness and drowsiness, patients should be cautioned about operating heavy machinery or engaging in activities requiring mental alertness until they know how methocarbamol affects them

A recent longitudinal imaging study showed a reduction of thalamus and basal ganglia volumes as well as aberrant diffusion markers in post-COVID patients, which correlated with fatigue scores [50]

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It is synthesized from three amino acids in two ATP-dependent steps, beginning with the formation of a peptide bond between -glutamate and cysteine by -glutamylcysteine synthetase (GSH1) and the subsequent addition of glycine, catalyzed by glutathione synthetase (GSH2) (Figure 1: GSH biosynthesis) [20]